Genetic Dissection of Litter-size Quantitative Trait Loci Located on Murine Chromosome 7
نویسندگان
چکیده
A significant quantitative trait locus (QTL) for murine litter size, Lsq1, was previously identified on chromosome 7 in the female backcross progeny of ♀(♀C57BL/6J × ♂RR/Sgn) ♂RR/Sgn (BRR mice). In present study, QTL mapping analysis performed same ♀(♀RR/Sgn ♂C57BL/6J) (RBR mice), and Lsq1 again. As size is significantly larger BRR mice than that RBR mice, potential effect grandparental cross direction indicated. combined data from showed split into two loci: Lsq1-1 Lsq1-2. The RR/Sgn strain-derived allele associated with reduced at both loci. Lsq1-2 exhibited effects number stillbirths but not increased Therefore, suggest depends smaller a consequence stillbirths. are suggested to be novel size.
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ژورنال
عنوان ژورنال: Jarq-japan Agricultural Research Quarterly
سال: 2023
ISSN: ['0021-3551', '2185-8896']
DOI: https://doi.org/10.6090/jarq.57.231